Boosting confidence in motifs via evolutionary conservation

The 'Your species' selection allows DILIMOT to be more intelligent about incorporating evolutionary conservation into the scoring of putative motifs. Important instances of linear motifs are normally preserved across closely related species (e.g. Human to Mouse; D. melanogaster to D. pseudoobscrua; C.elegans to C. briggsae). The SCONS score is a weighted combination of P-values for all species consisdered. In our experience, true motifs become much more significant when conservation is considered.